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Last updated: 05/09/2022

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Drug Name Classification Clinical Indication Comments
ADAPALENE / BENZOYL PEROXIDE TOPICAL (Epiduo®) Green Acne

For more information please see local algorithm.

ADAPALENE topical Green Acne

For more information see local algorithm.

AMANTADINE Yellow For fatigue in Multiple sclerosis

Amantadine for fatigue in Multiple sclerosis: prescribing notes

AMIKACIN (Arikayce Liposomal®) Red For the treatment of non-tuberculous mycobacterial pulmonary disease caused by Mycobacterium Avium Complex (MAC) adults and post pubescent children)
ANTIPSYCHOTICS-Atypical Yellow

See the LLR Antipsychotic prescribing guide

Clozapine remains red – secondary care only.

APIXABAN Green Prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation

Use in line with
DOAC in non valvular AF guide

ATROPINE EYE DROPS Green Palliative care in line with guidance

Conditional on recommendation from palliative care team.
Palliative Care Prescribing

AZATHIOPRINE Orange Rheumatological disease

Full SCA

AZELAIC ACID 20% TOPICAL Green Acne

See local algorithm for more information.

BECLOMETASONE DIPROPIONATE / FORMOTEROL (Fostair®) Green Asthma
COPD

Prescribe in line with respiratory guidelines

BIMATOPROST / TIMOLOL eye drops (Ganfort®) Green Glaucoma
BRINZOLAMIDE / BRIMONIDINE (Simbrinza®) eye drops Green Glaucoma
BRINZOLAMIDE / TIMOLOL (Azarga®) Green Glaucoma
CICLOSPORIN Oral Orange Dermatological disease

Full SCA

CIPROFLOXACIN 2mg/ml ear drops (Cetraxal®) Green Acute otitis externa

Please see appropriate antimicrobial guidance for treatment advice in otitis externa. Antimicrobial Guidance for Primary Care

CLINDAMYCIN AND BENZYL PEROXIDE TOPICAL (Duac ®) Green Acne

See local algorithm for more information

CLINDAMYCIN AND TRETINOIN TOPICAL (Treclin®) Green Acne

See local algorithm for more information.

DABIGATRAN Green Prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation

Use in line with
DOAC in non valvular AF guide

DENOSUMAB (Prolia®) Orange Osteoporosis

Full SCA

 

DIFELIKALIN (Kapruvia®) (NEW) Grey Moderate-to-severe pruritus associated with chronic kidney disease in adult patients on haemodialysis.
DULOXETINE Green Diabetic neuropathy

To be used in conjunction with Neuropathic Pain Guidelines

EDOXABAN Green Prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation

Use in line with
NICE TA355

See DOAC guide for non-valvular AF

EPTINEZUMAB (Vyepti®) (NEW) Grey For the prophylaxis of migraine in adults who have at least 4 migraine days per month.
ERTAPENEM IV Green Extended Spectrum Beta Lactamase (ESBL) Urinary Tract Infection (UTI)

UTI in line with Primary Care Multi-resistant lower UTI guidance

ESTRADIOL HEMIHYDRATE/NORETHISTERONE ACETATE/RELUGOLIX (Ryeqo ®) Red For treating moderate to severe symptoms of uterine fibroids.

In line with NICE TA832

 

FENTANYL Sublingual (Abstral®) Green Breakthrough cancer pain in patients already on opioids. Palliative care in line with guidance

Conditional on recommendation from palliative care team.
See: Palliative care – drugs for use only after specialist recommendation

FIDAXOMICIN Yellow Clostridium difficile infection

GP can initiate if in line with Community Clostridium difficile Care Pathway

FLUTICASONE / AZELASTINE NASAL SPRAY (Dymista®) Green Rhinitis

To be used in line with the Allergic Rhinitis Pathway

FOSTAMATINIB (Tavlesse®) Red For treating refractory chronic immune thrombocytopenia

In line with NICE TA835

 

GANCICLOVIR 0.15% EYE GEL Do not prescribe Acute herpetic keratitis

Only GREEN whilst Aciclovir eye ointment 3% is not available. Definite diagnosis only.

GLYCOPYRRONIUM LIQUID (Colonis®) Do not prescribe Sialorrhea in paediatrics

Patients started on Glycopyrronium liquid after 16th December 2022 should have been started on the Sialanar® brand.

GLYCOPYRRONIUM LIQUID (Sialanar®) Yellow Sialorrhoea in paediatrics

Switching to the Sialanar®  brand from another glycopyrronium liquid to be done by secondary care using the paper work which can be found on this page

GOSERELIN Green Prostatic carcinoma

GP can give first injection to patients in whom anti-androgen treatment has been started by secondary care clinician.

Local guidance

GRANISETRON oral and injection Green Palliative care in line with guidance

Conditional on recommendation from palliative care team.
Palliative Care Prescribing

GUANFACINE Orange ADHD - Adult

Adult Full SCA and Request Form

GUANFACINE Orange ADHD - Peadiatric

Paediatric Full SCA and Request Form

HYDROCORTISONE INJECTION Yellow Emergency HC injection kit

Kit for patients with Addison’s disease or high risk due to long term steroid use. Dose to be recommended by specialist.
HC Emergency Kit for Paediatrics: Prescribing and supply details

IMIQUIMOD cream 5% (Aldara®) Green Actinic keratoses
INDOCYANINE (Verdye®) Red Detection of sentinel lymph nodes in Endometrial cancer

Reviewed by TAS November 2022

INSULIN ASPART (Trurapi®) Green Insulin

New initiations only

KETAMINE Green Palliative care in line with guidance

Conditional on recommendation from palliative care team.
Palliative Care Prescribing

 

KETOROLAC Green Palliative care in line with guidance

Conditional on recommendation from palliative care team.

Palliative Care Prescribing

LANREOTIDE Green Palliative Care

Link to Palliative Care Guidelines

LATANOPROST preservative free eye drops Green Glaucoma
LEFLUNOMIDE Orange Rheumatological disease

Full SCA     Request form

LEUPRORELIN Green Prostate cancer (subcutaneous injection for patients at risk of haematoma)

GP can give first injection to patients in whom anti-androgen treatment has been started by secondary care clinician.

Local guidance

LEVETIRACETAM Green Palliative care in line with guidance

Conditional on recommendation from palliative care team.
Palliative Care Prescribing

LITHIUM SALTS Orange Mania, Bipolar Disorder, Recurrent Depression or Aggressive or Self-mutilating behaviour.

Full SCA     Request form

Luforbec 200/6 mdi® (formeterol/beclometasone) (NEW) Do not prescribe Treatment of asthma where use of a combination product (inhaled corticosteroid and long-acting beta2-agonist) is appropriate

At the request of the Respiratory Prescribing Group for formulary reasons.

METHADONE Green Palliative care in line with palliative care guidance.

Conditional on recommendation from palliative care team.
Palliative Care Prescribing

METHOTREXATE Oral Orange Rheumatological disease

Full SCA     Request form

METHYLNATREXONE Green Palliative care in line with guidance.

Conditional on recommendation from palliative care team.
Palliative Care Prescribing

METHYLPHENIDATE Green Palliative care in line with guidance

Conditional on recommendation from palliative care team.
Palliative Care Prescribing

MIDAZOLAM buccal Green Palliative care in line with guidance.

Conditional on recommendation from palliative care team.

Palliative Care Prescribing

MIRABEGRON Green Symptoms of urinary frequency, urgency and urge incontinence

In line with Overactive Bladder Pathway

NALOXONE Green Palliative care in line with guidance.

Conditional on recommendation from palliative care team.
Palliative Care Prescribing

OCTREOTIDE Green Palliative care in line with guidance

Conditional on recommendation from palliative care team.
Palliative Care Prescribing

OLANZAPINE Green Palliative care in line with guidance

Conditional on recommendation from palliative care team.
Palliative Care Prescribing

OLANZAPINE Oral Yellow Schizophrenia. Combination therapy for mania. Preventing recurrence in bipolar disorder. Monotherapy for mania. Control of agitation and disturbed behaviour in schizophrenia or mania. Personality disorder.

See the LLR Antipsychotic Prescribing Guide

OMEGA-3 ACID ETHYL ESTERS (Omacor®) (UPDATED) Green Hypertriglyceridaemia

In line with LLR lipid pathway

ONDANSETRON Green Nausea

Further information when used for palliative care can be found in the Palliative Care Prescribing Guide

OXYBUTYNIN patch Green Symptomatic treatment of urge incontinence in unstable bladder

For use only in patients who cannot take oral medication See Overactive bladder pathway

PENICILLAMINE Orange Rheumatoid arthritis

Full SCA

QUETIAPINE Green Palliative care in line with guidance.

Conditional on recommendation from palliative care team.
Palliative Care Prescribing

QUINIDINE Red Brugada syndrome

Reviewed by TAS November 2022

RIMEGEPANT (Vydura®) (NEW) Grey Migraine
RITUXIMAB Red Idiopathic membranous nephropathy
RIVAROXABAN Green Prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation

See DOAC in non valvular AF guide

ROMOSOZUMAB (Evenity®) Red Severe osteoporosis

In line with NICE TA791

 

SACUBITRIL / VALSARTAN (Entresto®) Yellow Heart failure

For background and information and monitoring requirements, (in line with ACEI/ARB monitoring for heart failure), please see interim information whilst the heart failure guide is being updated.

 

SOLIFENACIN / TAMSULOSIN (Vesomni®) Green Benign prostatic hyperplasia
SULFASALAZINE Orange Rheumatological disease

Full SCA

TEICOPLANIN Green Cellulitis (in primary care)

To be used in conjunction with the Cellulitis-Teicoplanin Pathway

TIOTROPIUM (Braltus Zonda®) Green COPD

Use in line with Leicestershire LAMA Prescribing Guide

 

TIRZEPATIDE (Mounjaro®) (NEW) Grey Treatment of adults with insufficiently controlled type 2 diabetes mellitus
TRIPTORELIN Yellow Precocious puberty

GP Guidance

TRIPTORELIN Green Prostatic carcinoma

GP can give first injection to patients in whom anti-androgen treatment has been started by secondary care clinician.

Local guidance

Other Updates on this Website

Recent documents from LLR APC and TAS

Osteoporosis(1 MB) - Guidelines

Version 3.1 Uploaded January 2023

Date added: 28th May 2015


About the Leicester, Leicestershire and Rutland Area Prescribing Committee

In common with other local health communities, the Leicester, Leicestershire and Rutland Area Prescribing Committee (LLR APC) acknowledges the benefits of having a Leicestershire Health Community-wide strategy for the prescribing of specialist medicines and the managed entry of new drugs and related technologies.

Leicestershire Health Community comprises the Leicester, Leicestershire and Rutland Integrated Care Board, University Hospitals of Leicester (UHL) NHS Trust and Leicestershire Partnership NHS Trust (LPT), amongst which there is a total consensus on the need for this strategy, and the LLR APC has been in place since 2005. Learn more